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A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement.
Woodruff, Tracey J; Rayasam, Swati D G; Axelrad, Daniel A; Koman, Patricia D; Chartres, Nicholas; Bennett, Deborah H; Birnbaum, Linda S; Brown, Phil; Carignan, Courtney C; Cooper, Courtney; Cranor, Carl F; Diamond, Miriam L; Franjevic, Shari; Gartner, Eve C; Hattis, Dale; Hauser, Russ; Heiger-Bernays, Wendy; Joglekar, Rashmi; Lam, Juleen; Levy, Jonathan I; MacRoy, Patrick M; Maffini, Maricel V; Marquez, Emily C; Morello-Frosch, Rachel; Nachman, Keeve E; Nielsen, Greylin H; Oksas, Catherine; Abrahamsson, Dimitri Panagopoulos; Patisaul, Heather B; Patton, Sharyle; Robinson, Joshua F; Rodgers, Kathryn M; Rossi, Mark S; Rudel, Ruthann A; Sass, Jennifer B; Sathyanarayana, Sheela; Schettler, Ted; Shaffer, Rachel M; Shamasunder, Bhavna; Shepard, Peggy M; Shrader-Frechette, Kristin; Solomon, Gina M; Subra, Wilma A; Vandenberg, Laura N; Varshavsky, Julia R; White, Roberta F; Zarker, Ken; Zeise, Lauren.
Affiliation
  • Woodruff TJ; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA. Tracey.Woodruff@ucsf.edu.
  • Rayasam SDG; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
  • Axelrad DA; Independent Consultant, Washington, DC, USA.
  • Koman PD; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Chartres N; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
  • Bennett DH; Department of Public Health Sciences, University of California, Davis, Davis, CA, USA.
  • Birnbaum LS; National Institutes of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC, USA.
  • Brown P; Duke University, Durham, NC, USA.
  • Carignan CC; Social Science Environmental Health Research Institute, Northeastern University, Boston, MA, USA.
  • Cooper C; Department of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
  • Cranor CF; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
  • Diamond ML; Department of Philosophy, University of California, Riverside, Riverside, CA, USA.
  • Franjevic S; Environmental Toxicology Graduate Program, College of Natural and Agricultural Sciences, University of California, Riverside, Riverside, CA, USA.
  • Gartner EC; Department of Earth Sciences, University of Toronto, Toronto, ON, Canada.
  • Hattis D; School of the Environment, University of Toronto, Toronto, ON, Canada.
  • Hauser R; Clean Production Action, Somerville, MA, USA.
  • Heiger-Bernays W; Earthjustice, New York, NY, USA.
  • Joglekar R; The George Perkins Marsh Institute, Clark University, Worcester, MA, USA.
  • Lam J; Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Levy JI; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
  • MacRoy PM; Earthjustice, New York, NY, USA.
  • Maffini MV; Department of Public Health, California State University, East Bay, Hayward, CA, USA.
  • Marquez EC; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
  • Morello-Frosch R; Defend Our Health, Portland, ME, USA.
  • Nachman KE; Independent Consultant, Washington, DC, USA.
  • Nielsen GH; Pesticide Action Network, Berkeley, CA, USA.
  • Oksas C; School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
  • Abrahamsson DP; Department of Environmental Science, Policy and Management, University of California, Berkeley, Berkeley, CA, USA.
  • Patisaul HB; Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Patton S; Johns Hopkins Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Robinson JF; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
  • Rodgers KM; School of Medicine, University of California, San Francisco, CA, USA.
  • Rossi MS; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
  • Rudel RA; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
  • Sass JB; , Commonweal, Bolinas, CA, USA.
  • Sathyanarayana S; Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
  • Schettler T; Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
  • Shaffer RM; Silent Spring Institute, Newton, MA, USA.
  • Shamasunder B; Clean Production Action, Somerville, MA, USA.
  • Shepard PM; Silent Spring Institute, Newton, MA, USA.
  • Shrader-Frechette K; Natural Resources Defense Council, Washington, DC, USA.
  • Solomon GM; Department of Pediatrics, University of Washington, Seattle, WA, USA.
  • Subra WA; Department of Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, USA.
  • Vandenberg LN; Science and Environmental Health Network, Ames, IA, USA.
  • Varshavsky JR; Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, USA.
  • White RF; Department of Urban & Environmental Policy and Public Health, Occidental College, Los Angeles, CA, USA.
  • Zarker K; WE ACT for Environmental Justice, New York, NY, USA.
  • Zeise L; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Environ Health ; 21(Suppl 1): 132, 2023 01 12.
Article in En | MEDLINE | ID: mdl-36635734
ABSTRACT
The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk assessment and risk management analyses (1) the financial burden of data generation for any given chemical on (or to be introduced to) the market should be on the chemical producers that benefit from their production and use; (2) lack of data does not equate to lack of hazard, exposure, or risk; (3) populations at greater risk, including those that are more susceptible or more highly exposed, must be better identified and protected to account for their real-world risks; (4) hazard and risk assessments should not assume existence of a "safe" or "no-risk" level of chemical exposure in the diverse general population; and (5) hazard and risk assessments must evaluate and account for financial conflicts of interest in the body of evidence. While many of these recommendations focus specifically on the EPA, they are general principles for environmental health that could be adopted by any agency or entity engaged in exposure, hazard, and risk assessment. We also detail recommendations for four priority areas in companion papers (exposure assessment methods, human variability assessment, methods for quantifying non-cancer health outcomes, and a framework for defining chemical classes). These recommendations constitute key steps for improved evidence-based environmental health decision-making and public health protection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Environmental Pollutants Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Aspects: Equity_inequality Limits: Humans Language: En Journal: Environ Health Journal subject: SAUDE AMBIENTAL Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Environmental Pollutants Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Aspects: Equity_inequality Limits: Humans Language: En Journal: Environ Health Journal subject: SAUDE AMBIENTAL Year: 2023 Document type: Article Affiliation country: United States