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A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer.
Takagi, Tadayuki; Sugimoto, Mitsuru; Imamura, Hidemichi; Takahata, Yosuke; Nakajima, Yuki; Suzuki, Rei; Konno, Naoki; Asama, Hiroyuki; Sato, Yuki; Irie, Hiroki; Nakamura, Jun; Takasumi, Mika; Hashimoto, Minami; Kato, Tsunetaka; Kobashi, Ryoichiro; Hashimoto, Yuko; Shibukawa, Goro; Marubashi, Shigeru; Hikichi, Takuto; Ohira, Hiromasa.
Affiliation
  • Takagi T; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Sugimoto M; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Imamura H; Department of Gastroenterology, Ohtanishinouchi Hospital, Koriyama, Japan.
  • Takahata Y; Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
  • Nakajima Y; Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
  • Suzuki R; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Konno N; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Asama H; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Sato Y; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Irie H; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Nakamura J; Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
  • Takasumi M; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Hashimoto M; Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
  • Kato T; Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
  • Kobashi R; Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
  • Hashimoto Y; Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Shibukawa G; Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
  • Marubashi S; Department of Hepato-Biliary-Pancreatic and Transplant Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
  • Hikichi T; Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
  • Ohira H; Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Clin Endosc ; 56(1): 107-113, 2023 Jan.
Article in En | MEDLINE | ID: mdl-36646425
BACKGROUND/AIMS: Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC. METHODS: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018-2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA. RESULTS: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. CONCLUSION: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Clin Endosc Year: 2023 Document type: Article Affiliation country: Japan Country of publication: Korea (South)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Clin Endosc Year: 2023 Document type: Article Affiliation country: Japan Country of publication: Korea (South)