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Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Xu, Jun; Wang, Qinggong; Hübner, Harald; Hu, Yunfei; Niu, Xiaogang; Wang, Haoqing; Maeda, Shoji; Inoue, Asuka; Tao, Yuyong; Gmeiner, Peter; Du, Yang; Jin, Changwen; Kobilka, Brian K.
Affiliation
  • Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Wang Q; Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, 100084, Beijing, China.
  • Hübner H; Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong, 518172, Shenzhen, China.
  • Hu Y; Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, P. R. China.
  • Niu X; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University, 91058, Erlangen, Germany.
  • Wang H; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, 100084, Beijing, China.
  • Maeda S; Innovation Academy for Precision Measurement Science and Technology, CAS, 430071, Wuhan, China.
  • Inoue A; Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, 100084, Beijing, China.
  • Tao Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Gmeiner P; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Du Y; Department of Pharmacology, Medical School, University of Michigan 1150 Medical Center Dr., 1315 Medical Science Research Bldg III, Ann Arbor, MI, 48109, USA.
  • Jin C; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
  • Kobilka BK; Division of Life Sciences and Medicine, University of Science and Technology of China, 230027, Hefei, P. R. China.
Nat Commun ; 14(1): 376, 2023 01 23.
Article in En | MEDLINE | ID: mdl-36690613
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholine / Receptors, Muscarinic Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholine / Receptors, Muscarinic Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom