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Biomarkers in osteoarthritis: current status and outlook - the FNIH Biomarkers Consortium PROGRESS OA study.
Hunter, David J; Collins, Jamie E; Deveza, Leticia; Hoffmann, Steven C; Kraus, Virginia B.
Affiliation
  • Hunter DJ; Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine, University of Sydney, Australia and Rheumatology Department, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia. David.Hunter@sydney.edu.au.
  • Collins JE; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Deveza L; Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine, University of Sydney, Australia and Rheumatology Department, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
  • Hoffmann SC; Foundation for the National Institutes of Health, Bethesda, North, MD, USA.
  • Kraus VB; Duke Molecular Physiology Institute, and Department of Medicine|, Duke University, Durham, NC, USA.
Skeletal Radiol ; 52(11): 2323-2339, 2023 Nov.
Article in En | MEDLINE | ID: mdl-36692532
Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints' limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigating biomarkers for a prognostic context of use for subsequent qualification through regulatory agencies. This narrative review describes this activity and the work underway, focusing on the PROGRESS OA study.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Skeletal Radiol Year: 2023 Document type: Article Affiliation country: Australia Country of publication: Germany
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Skeletal Radiol Year: 2023 Document type: Article Affiliation country: Australia Country of publication: Germany