Your browser doesn't support javascript.
loading
NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature.
Dhodapkar, Rahul M; Spadaro, Jane Z; Heng, Jacob S; Sinard, John H; Lee, Yan Ho; Habib, Larissa A; Pointdujour-Lim, Renelle.
Affiliation
  • Dhodapkar RM; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Spadaro JZ; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Heng JS; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Sinard JH; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Lee YH; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Habib LA; Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, U.S.A.
  • Pointdujour-Lim R; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, U.S.A.
Ophthalmic Plast Reconstr Surg ; 39(4): 316-327, 2023.
Article in En | MEDLINE | ID: mdl-36692957
PURPOSE: To present the clinical course of a patient with recurrent NK/T-cell lymphoma (NKTL) involving the orbit and to review the literature on patients with NKTL involving the orbit. METHODS: The PubMed database was searched for all cases of NKTL involving orbital, intraocular, or adnexal ocular structures. RESULTS: Ninety-six patients were included in the final analysis. The mean age of diagnosis was 48.1 ± 16.8 years. The patients were 53/96 (55.2%) male and 43/96 (44.8%) female. Tumor location varied and included the orbit in 80/96 (83.3%), nasosinus in 56/96 (58.3%), uvea in 11/96 (11.5%), lacrimal gland in 9/96 (9.4%), lacrimal drainage system in 11/96 (11.5%), and conjunctiva in 7/96 (7.3%) cases. Management included surgical debulking in 29/96 (30.2%) cases, radiotherapy in 52/96 (54.2%) cases, and chemotherapy in 82/96 (85.4%) cases. Median survival was 6 months (95% CI: 5-9). Chemotherapy (hazard ratio = 0.80, 95% CI: 0.67-0.95, p = 0.013), radiotherapy (hazard ratio = 0.75, 95% CI: 0.64-0.87, p < 0.001), and orbital involvement being a recurrence of disease (hazard ratio = 0.79, 95% CI: 0.67-0.95, p = 0.009) were associated with improved survival. Advanced Ann Arbor stage (III-IV) at diagnosis (hazard ratio = 1.22, 95% CI: 1.08-1.38, p = 0.001), vision loss (hazard ratio = 1.18, 95% CI: 1.04-1.34, p = 0.009), proptosis (hazard ratio = 1.15, 95% CI: 1.01-1.30, p = 0.035) and periorbital swelling (hazard ratio = 1.15, 95% CI: 1.00-1.33, p = 0.048) were associated with poor survival. CONCLUSIONS: NK/T-cell lymphoma involving the orbit, globe, or ocular adnexa heralds a poor prognosis where early diagnosis and therapy are critical. The use of radiotherapy and chemotherapy is associated with improved survival.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orbital Neoplasms / Lymphoma, T-Cell / Lacrimal Apparatus Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Ophthalmic Plast Reconstr Surg Journal subject: OFTALMOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orbital Neoplasms / Lymphoma, T-Cell / Lacrimal Apparatus Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies / Systematic_reviews Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Ophthalmic Plast Reconstr Surg Journal subject: OFTALMOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States