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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Panek, Dawid; Pasieka, Anna; Latacz, Gniewomir; Zareba, Paula; Szczech, Michal; Godyn, Justyna; Chantegreil, Fabien; Nachon, Florian; Brazzolotto, Xavier; Skrzypczak-Wiercioch, Anna; Walczak, Maria; Smolik, Magdalena; Salat, Kinga; Höfner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara.
Affiliation
  • Panek D; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland. Electronic address: dawid.panek@uj.edu.pl.
  • Pasieka A; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Zareba P; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Szczech M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Godyn J; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Chantegreil F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91223, Brétigny sur Orge, France.
  • Nachon F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91223, Brétigny sur Orge, France.
  • Brazzolotto X; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91223, Brétigny sur Orge, France.
  • Skrzypczak-Wiercioch A; Department of Animal Anatomy and Preclinical Sciences, University Centre of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Mickiewicza 24/28, 30-059, Kraków, Poland.
  • Walczak M; Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St. 9, 30-688, Krakow, Poland.
  • Smolik M; Chair and Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St. 9, 30-688, Krakow, Poland.
  • Salat K; Department of Pharmacodynamics, Chair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Krakow, Poland.
  • Höfner G; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr, 5-13, 81377, Munich, Germany.
  • Wanner K; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstr, 5-13, 81377, Munich, Germany.
  • Wieckowska A; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
  • Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna St. 9, 30-688, Kraków, Poland.
Eur J Med Chem ; 249: 115135, 2023 Mar 05.
Article in En | MEDLINE | ID: mdl-36696766
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrylcholinesterase / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrylcholinesterase / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Country of publication: France