SorCS1 inhibits amyloid-ß binding to neurexin and rescues amyloid-ß-induced synaptic pathology.

Lee, Alfred Kihoon; Yi, Nayoung; Khaled, Husam; Feller, Benjamin; Takahashi, Hideto

Lee, Alfred Kihoon; Yi, Nayoung; Khaled, Husam; Feller, Benjamin; Takahashi, Hideto.

Affiliation

Lee AK; Synapse Development and Plasticity Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Canada.
Yi N; Integrated Program in Neuroscience, McGill University, Montreal, Canada.
Khaled H; Synapse Development and Plasticity Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Canada.
Feller B; Department of Medicine, Université de Montréal, Montreal, Canada.
Takahashi H; Synapse Development and Plasticity Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Canada.

Life Sci Alliance ; 6(4)2023 04.

Article in En | MEDLINE | ID: mdl-36697254

Subject(s)

Alzheimer Disease; Amyloid beta-Peptides; Receptors, Cell Surface; Humans; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Axons/metabolism; Neurons/metabolism; Synapses/metabolism; Receptors, Cell Surface/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Receptors, Cell Surface / Alzheimer Disease Limits: Humans Language: En Journal: Life Sci Alliance Year: 2023 Document type: Article Affiliation country: Canada Country of publication: United States

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