Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis in rats: Possible role of SIRT1/Nrf2/HO-1 pathway.

Abu-Risha, Sally E; Sokar, Samia S; Elbohoty, Heba R; Elsisi, Alaa E

Abu-Risha, Sally E; Sokar, Samia S; Elbohoty, Heba R; Elsisi, Alaa E.

Affiliation

Abu-Risha SE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Sokar SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Elbohoty HR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address: PG_123839@Pharm.tanta.edu.eg.
Elsisi AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Int Immunopharmacol ; 116: 109750, 2023 Mar.

Article in En | MEDLINE | ID: mdl-36709594

Subject(s)

Antioxidants; Silymarin; Rats; Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use; Antioxidants/metabolism; Cilostazol/therapeutic use; Cilostazol/pharmacology; Sirtuin 1/metabolism; NF-E2-Related Factor 2/metabolism; Ethanol/metabolism; Liver Cirrhosis/chemically induced; Liver Cirrhosis/drug therapy; Liver Cirrhosis/metabolism; Liver/pathology; Silymarin/pharmacology; Silymarin/therapeutic use; Oxidative Stress; Cytokines/metabolism; Anti-Inflammatory Agents/pharmacology

Key words

Alcohol; Carvacrol; Cilostazol; Hepatic fibrosis; Oxidative stress; SIRT1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silymarin / Antioxidants Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: Netherlands

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