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A case-control study of the association between the gut microbiota and colorectal cancer: exploring the roles of diet, stress, and race.
Carson, Tiffany L; Byrd, Doratha A; Smith, Kristen S; Carter, Daniel; Abaskaron, Michael; Little, Rebecca B; Holmes, Sh'Nese Townsend; van Der Pol, William J; Lefkowitz, Elliot J; Morrow, Casey D; Fruge, Andrew D; Gomez, Maria.
Affiliation
  • Carson TL; Moffitt Cancer Center.
  • Byrd DA; Moffitt Cancer Center.
  • Smith KS; Moffitt Cancer Center.
  • Carter D; Auburn University.
  • Abaskaron M; Moffitt Cancer Center.
  • Little RB; University of Alabama at Birmingham.
  • Holmes ST; University of Alabama at Birmingham.
  • van Der Pol WJ; University of Alabama at Birmingham.
  • Lefkowitz EJ; University of Alabama at Birmingham.
  • Morrow CD; University of Alabama at Birmingham.
  • Fruge AD; Auburn University.
  • Gomez M; Moffitt Cancer Center.
Res Sq ; 2023 Jan 19.
Article in En | MEDLINE | ID: mdl-36711747
ABSTRACT

Background:

The gut microbiota is associated with risk for colorectal cancer (CRC), a chronic disease for which racial disparities persist with Black Americans having a higher risk of CRC incidence and mortality compared to other groups. Given documented racial differences, the gut microbiota may offer some insight into previously unexplained racial disparities in CRC incidence and mortality. A case-control analysis comparing 11 women newly diagnosed with CRC with 22 cancer-free women matched on age, BMI, and race in a 12 ratio was conducted. Information about participants' diet and perceived stress levels were obtained via 24-hour Dietary Recall and Perceived Stress Scale-10 survey, respectively. Participants provided stool samples from which microbial genomic DNA was extracted to reveal the abundance of 26 genera chosen a priori based on their previously observed relevance to CRC, anxiety symptoms, and diet.

Results:

Significantly lower alpha diversity was observed among cancer-free Black women compared to all other race-cancer status combinations. No group differences were observed when comparing beta diversity. Non-Hispanic White CRC cases tended to have higher relative abundance of Fusobacteria, Gemellaceae, and Peptostreptococcus compared to all other race-cancer combination groups. Perceived stress was inversely associated with alpha diversity and was associated with additional genera.

Conclusions:

Our findings suggest that microbiome-CRC associations may differ by racial group. Additional large, racially diverse population-based studies are needed to determine if previously identified associations between characteristics of the gut microbiome and CRC are generalizable to Black women and other racial, ethnic, and gender groups.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Language: En Journal: Res Sq Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Language: En Journal: Res Sq Year: 2023 Document type: Article