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Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial.
Bian, Huijie; Chen, Liang; Zheng, Zhao-Hui; Sun, Xiu-Xuan; Geng, Jie-Jie; Chen, Ruo; Wang, Ke; Yang, Xu; Chen, Shi-Rui; Chen, Si-Yu; Xie, Rong-Hua; Zhang, Kui; Miao, Jin-Lin; Jia, Jun-Feng; Tang, Hao; Liu, Shuang-Shuang; Shi, Hong-Wei; Yang, Yong; Chen, Xiao-Chun; Malhotra, Vinay; Nasir, Nosheen; Khanum, Iffat; Mahmood, Faisal; Hamid, Saeed; Stadnik, Claudio Marcel Berdun; Itinose, Kengi; de Oliveira, Caroline Cândida Carvalho; Dusilek, Cesar; Rivabem, Lucas; Cavalcante, Adilson Joaquim Westheimer; Lopes, Suzara Souto; Saporito, Wladmir Faustino; Fucci, Fábio José Concilio; Simon-Campos, Jesus Abraham; Wang, Ling; Liu, Lin-Na; Wang, Qing-Yi; Wei, Ding; Zhang, Zheng; Chen, Zhi-Nan; Zhu, Ping.
Affiliation
  • Bian H; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Chen L; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, China.
  • Zheng ZH; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Sun XX; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Geng JJ; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Chen R; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang K; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Yang X; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Chen SR; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Chen SY; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Xie RH; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang K; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Miao JL; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Jia JF; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Tang H; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.
  • Liu SS; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.
  • Shi HW; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.
  • Yang Y; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.
  • Chen XC; Jiangsu Pacific Meinuoke Biopharmaceutical Co. Ltd, Changzhou, China.
  • Malhotra V; Pulse Heart Institute Cardiology Services, MultiCare Institute for Research & Innovation, Tacoma, WA, USA.
  • Nasir N; Department of Medicine, The Aga Khan University, Karachi, Pakistan.
  • Khanum I; Department of Medicine, The Aga Khan University, Karachi, Pakistan.
  • Mahmood F; Department of Medicine, The Aga Khan University, Karachi, Pakistan.
  • Hamid S; Department of Medicine, The Aga Khan University, Karachi, Pakistan.
  • Stadnik CMB; Infection Control Service, Irmandade Santa Casa de Misericord de Porto Alegre, Porto Alegre, Brazil.
  • Itinose K; Clinical Research Department, Hospital do Rocio, Campo Largo, Brazil.
  • de Oliveira CCC; Clinical Research Department, Hospital do Rocio, Campo Largo, Brazil.
  • Dusilek C; Clinical Research Department, Hospital do Rocio, Campo Largo, Brazil.
  • Rivabem L; Clinical Research Department, Hospital do Rocio, Campo Largo, Brazil.
  • Cavalcante AJW; CEMEC-Centro Multidisciplinar de Estudos Clínicos, São Bernardo do Campo, Brazil.
  • Lopes SS; Chronos Pesquisa Clinica, Brasília, Brazil.
  • Saporito WF; Pesquisare Saúde, Santo André, Brazil.
  • Fucci FJC; Instituto de Moléstias Cardiovasculares Tatuí, Tatuí, Brazil.
  • Simon-Campos JA; Kohler & Milstein Research /Hospital Agustín O'Horán, Mérida, Mexico.
  • Wang L; College of Military Preventive Medicine, Fourth Military Medical University, Xi'an, China.
  • Liu LN; Department of Pharmaceutics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang QY; Department of Foreign Languages, Fourth Military Medical University, Xi'an, China.
  • Wei D; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China. weidcq@fmmu.edu.cn.
  • Zhang Z; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China. cerc@aliyun.com.
  • Chen ZN; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China. znchen@fmmu.edu.cn.
  • Zhu P; Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital, Fourth Military Medical University, Xi'an, China. zhuping@fmmu.edu.cn.
Signal Transduct Target Ther ; 8(1): 46, 2023 01 30.
Article in En | MEDLINE | ID: mdl-36717539
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Type of study: Clinical_trials Limits: Adult / Humans Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Affiliation country: China Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Type of study: Clinical_trials Limits: Adult / Humans Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Affiliation country: China Country of publication: United kingdom