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Inhibition of menin, BCL-2, and FLT3 combined with a hypomethylating agent cures NPM1/FLT3-ITD/-TKD mutant acute myeloid leukemia in a patient-derived xenograft model.
Carter, Bing Z; Mak, Po Yee; Tao, Wenjing; Ostermann, Lauren B; Mak, Duncan H; Ke, Baozhen; Ordentlich, Peter; McGeehan, Gerard M; Andreeff, Michael.
Affiliation
  • Carter BZ; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX. bicarter@mdanderson.org.
  • Mak PY; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Tao W; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Ostermann LB; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Mak DH; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Ke B; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Ordentlich P; Syndax, Waltham, MA.
  • McGeehan GM; Syndax, Waltham, MA.
  • Andreeff M; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX. mandreef@mdanderson.org.
Haematologica ; 108(9): 2513-2519, 2023 09 01.
Article in En | MEDLINE | ID: mdl-36727398
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute Limits: Animals / Humans Language: En Journal: Haematologica Year: 2023 Document type: Article
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute Limits: Animals / Humans Language: En Journal: Haematologica Year: 2023 Document type: Article