Glycochenodeoxycholate and glycodeoxycholate 3-O-glucuronides, but not hexadecanedioate and tetradecanedioate, detected weak inhibition of OATP1B caused by GDC-0810 in humans.

Yoshida, Kenta; Jaochico, Allan; Mao, Jialin; Sangaraju, Dewakar

Yoshida, Kenta; Jaochico, Allan; Mao, Jialin; Sangaraju, Dewakar.

Affiliation

Yoshida K; Clinical Pharmacology, Genentech Inc., South San Francisco, California, USA.
Jaochico A; Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.
Mao J; Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.
Sangaraju D; Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.

Br J Clin Pharmacol ; 89(6): 1903-1907, 2023 06.

Article in En | MEDLINE | ID: mdl-36735594

Subject(s)

Glucuronides; Glycochenodeoxycholic Acid; Humans; Glycodeoxycholic Acid; Cinnamates; Membrane Transport Proteins; Drug Interactions; Biomarkers

Key words

OATP1B; biomarkers; drug transporters; drug-drug interaction

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glucuronides / Glycochenodeoxycholic Acid Limits: Humans Language: En Journal: Br J Clin Pharmacol Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google