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A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia.
Wang, Yu-Hung; Yao, Chi-Yuan; Lin, Chien-Chin; Gurashi, Kristian; Amaral, Fabio M R; Bossenbroek, Hasse; Jerez, Andres; Somervaille, Tim C P; Binder, Moritz; Patnaik, Mrinal M; Hou, Hsin-An; Chou, Wen-Chien; Batta, Kiran; Wiseman, Daniel H; Tien, Hwei-Fang.
Affiliation
  • Wang YH; Division of Cancer Sciences, The University of Manchester, Manchester, UK.
  • Yao CY; Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
  • Lin CC; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, Manchester, UK.
  • Gurashi K; Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
  • Amaral FMR; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Bossenbroek H; Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
  • Jerez A; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Somervaille TCP; Division of Cancer Sciences, The University of Manchester, Manchester, UK.
  • Binder M; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, Manchester, UK.
  • Patnaik MM; Division of Cancer Sciences, The University of Manchester, Manchester, UK.
  • Hou HA; Haematology Department, Hospital Morales Meseguer, Murcia, Spain.
  • Chou WC; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, Manchester, UK.
  • Batta K; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Wiseman DH; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Tien HF; Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
Br J Haematol ; 201(2): 302-307, 2023 04.
Article in En | MEDLINE | ID: mdl-36746431
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Leukemia, Myelomonocytic, Chronic / Leukemia, Myeloid, Acute Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2023 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Leukemia, Myelomonocytic, Chronic / Leukemia, Myeloid, Acute Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2023 Document type: Article Country of publication: United kingdom