Drug Synergism as the Basis of Rational Neuroprotection.
Neurosci Behav Physiol
; 52(8): 1207-1211, 2022.
Article
in En
| MEDLINE
| ID: mdl-36748019
ABSTRACT
Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic investigation of the effects of combinations of drugs. An approach based on studying detailed mechanisms of action suggested combinations of drugs with the greatest possible synergism (by summation and potentiation of effects) for various directions in the treatment of neurological diseases. Examples of rational neuroprotection are considered, using Cortexin, citicoline, and antioxidants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Neurosci Behav Physiol
Year:
2022
Document type:
Article
Affiliation country:
RUSSIA