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Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia.
Aizawa, Chiharu; Okabe, Masahiro; Takahashi, Daisuke; Sagasaki, Makoto; Watanabe, Mao; Fujimoto, Toshinari; Yoshioka, Yuuki; Katsuma, Ai; Kimura, Ai; Miyamoto, Daisuke; Sato, Nana; Okamoto, Ken; Ichida, Kimiyoshi; Miyazaki, Yoichi; Yokoo, Takashi.
Affiliation
  • Aizawa C; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Okabe M; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Takahashi D; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, Japan.
  • Sagasaki M; Sumire Kidney Clinic, Japan.
  • Watanabe M; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Fujimoto T; Department of Nephrology and Hypertension, Atsugi City Hospital, Japan.
  • Yoshioka Y; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Katsuma A; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, Japan.
  • Kimura A; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Miyamoto D; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, Japan.
  • Sato N; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Okamoto K; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, Japan.
  • Ichida K; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
  • Miyazaki Y; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University Daisan Hospital, Japan.
  • Yokoo T; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Japan.
Intern Med ; 62(18): 2725-2730, 2023 Sep 15.
Article in En | MEDLINE | ID: mdl-36754409
ABSTRACT
Exercise-induced acute kidney injury (EIAKI) is frequently complicated with renal hypouricemia (RHUC). In patients with RHUC, limiting anaerobic exercise can prevent EIAKI. However, it is challenging to reduce exercise intensity in athletes. We herein report a 16-year-old Japanese football player with familial RHUC with compound heterozygous mutations in urate transporter 1 (URAT1) who presented with recurrent EIAKI. As prophylaxis (hydration during exercise) could not prevent EIAKI, febuxostat was initiated. EIAKI was not observed for 16 months despite exercising intensively. Hence, non-purine-selective xanthine oxidoreductase inhibitors may decrease the incidence of EIAKI in athletes with RHUC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organic Anion Transporters / Acute Kidney Injury Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organic Anion Transporters / Acute Kidney Injury Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country: Japan