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The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.
Song, Liu; Wang, Dianbing; Abbas, Ghulam; Li, Min; Cui, Mengmeng; Wang, Jufang; Lin, Zhanglin; Zhang, Xian-En.
Affiliation
  • Song L; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Wang D; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Abbas G; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Li M; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Cui M; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Wang J; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address: jufwang@scut.edu.cn.
  • Lin Z; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
  • Zhang XE; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address: zhangxe@ibp.ac.cn.
J Biol Chem ; 299(3): 102990, 2023 03.
Article in En | MEDLINE | ID: mdl-36758802
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / COVID-19 Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / COVID-19 Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country: China Country of publication: United States