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tRNA derived fragments:A novel player in gene regulation and applications in cancer.
Zhang, Shuangshuang; Yu, Xiuchong; Xie, Yaoyao; Ye, Guoliang; Guo, Junming.
Affiliation
  • Zhang S; Department of Gastroenterology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
  • Yu X; Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, School of Medicine, Ningbo University, Ningbo, China.
  • Xie Y; Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, School of Medicine, Ningbo University, Ningbo, China.
  • Ye G; Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, School of Medicine, Ningbo University, Ningbo, China.
  • Guo J; Department of Gastroenterology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Front Oncol ; 13: 1063930, 2023.
Article in En | MEDLINE | ID: mdl-36761955
The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation, has been demonstrated. In this review, we briefly summarize the current literatures on the classification of tRFs and the effects of tRNA modification on tRF biogenesis. Moreover, we highlight the tRF repertoire of biological roles such as gene silencing, and regulation of translation, cell apoptosis, and epigenetics. We also summarize the biological roles of various tRFs in cancer development and viral infection, their potential value as diagnostic and prognostic biomarkers for different types of cancers, and their potential use in cancer therapy.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Oncol Year: 2023 Document type: Article Affiliation country: China Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Oncol Year: 2023 Document type: Article Affiliation country: China Country of publication: Switzerland