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Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential.
Carneiro, Marcos Rodrigo Beltrão; Sallum, Lóide Oliveira; Martins, José Luís Rodrigues; Peixoto, Josana de Castro; Napolitano, Hamilton Barbosa; Rosseto, Lucimar Pinheiro.
Affiliation
  • Carneiro MRB; Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil.
  • Sallum LO; Campus Central, State University of Goiás, Anápolis 75132-400, Brazil.
  • Martins JLR; Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil.
  • Peixoto JC; Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil.
  • Napolitano HB; Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil.
  • Rosseto LP; Campus Central, State University of Goiás, Anápolis 75132-400, Brazil.
Molecules ; 28(3)2023 Jan 25.
Article in En | MEDLINE | ID: mdl-36770856
The genus Justicia has more than 600 species distributed in both hemispheres, in the tropics and temperate regions, and it is used in the treatment of numerous pathologies. This study presents a review of the biological activities of plant extracts and isolated chemical constituents of Justicia (ACANTHACEAE), identified in the period from May 2011 to August 2022. We analyzed over 176 articles with various biological activities and chemical compound descriptions present in the 29 species of Justicia. These have a variety of applications, such as antioxidant and antimicrobial, with alkaloids and flavonoids (e.g., naringenin) the most frequently identified secondary metabolites. The most observed species were Justicia gendarussa Burm., Justicia procumbens L., Justicia adhatoda L., Justicia spicigera Schltdl, and Justicia pectoralis Jacq. The frontier molecular orbitals carried out using density functional theory (M062X and basis set 6-311++G(d,p) indicate reactive sites for naringenin compound and a chemical reaction on phytomedicine activity. The energy gap (206.99 kcal/mol) and dimer solid state packing point to chemical stability. Due to the wide variety of pharmacological uses of these species, this review points toward the development of new phytomedicines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acanthaceae / Justicia / Alkaloids Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acanthaceae / Justicia / Alkaloids Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: Switzerland