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IP3Rs puff along: A SNAPpy dance with IP3 and Ca2.
Nakhe, Arya Y; Jacobson, David A.
Affiliation
  • Nakhe AY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
  • Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA. Electronic address: david.a.jacobson@vanderbilt.edu.
J Biol Chem ; 299(3): 103010, 2023 03.
Article in En | MEDLINE | ID: mdl-36773801
ABSTRACT
Concerted openings of clustered inositol 1,4,5-trisphosphate receptors (IP3Rs) result in short, localized Ca2+ bursts, also called puffs, which are crucial regulators of Ca2+-dependent signaling processes. However, the processes regulating Ca2+ puff amplitude (average ∼0.5 ΔF/F0) and duration (at half-maximal; average ∼25-30 ms) have yet to be elucidated. A recent study in JBC by Smith and Taylor determined that Ca2+ puff amplitude is independent of IP3R cluster density and that the termination of IP3R Ca2+ puff is regulated by IP3 dissociation, illuminating the steps of this regulatory dance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inositol 1,4,5-Trisphosphate / Calcium Signaling Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inositol 1,4,5-Trisphosphate / Calcium Signaling Language: En Journal: J Biol Chem Year: 2023 Document type: Article Affiliation country: United States