Treating fibromyalgia with electrical neuromodulation: A systematic review and meta-analysis.
Clin Neurophysiol
; 148: 17-28, 2023 04.
Article
in En
| MEDLINE
| ID: mdl-36774784
ABSTRACT
OBJECTIVE:
Several types of electrical neuromodulation (such as transcranial direct current stimulation, tDCS; transcutaneous electrical nerve stimulation) have been applied in the treatment of fibromyalgia. These trials had different outcome measurements, such as subjective pain, pain threshold, depression, anxiety, and functioning. We intended to integrate data from different trials into a meta-analysis to clearly present the clinical value of electrical neuromodulation in fibromyalgia.METHODS:
A systematic review and meta-analysis of randomized controlled trials comparing the effect of all types of electrical neuromodulation in patients with fibromyalgia was conducted. The main outcome was subjective pain; the secondary outcomes included depression, anxiety, and functioning.RESULTS:
Twenty-five studies and 1061 fibromyalgia patients were included in the quantitative analysis. Active electrical neuromodulation and active tDCS both showed significant effects on subjective pain, depression, and functioning. For different anode tDCS electrode positions, only F3-F4 revealed a significant effect on depression. Meta-regression tDCS effects on depression were significantly associated with age.CONCLUSIONS:
Electrical neuromodulation is significantly effective in treating pain, depression, and functioning in patients with fibromyalgia.SIGNIFICANCE:
The results may help clinicians to arrange effective treatment plans for patients with fibromyalgia, especially in those patients who reveal limited response to pharmacotherapy and psychotherapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fibromyalgia
/
Transcutaneous Electric Nerve Stimulation
/
Transcranial Direct Current Stimulation
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2023
Document type:
Article