Sleep irregularity and the association with hypertension and blood pressure levels: the ELSA-Brasil study.
J Hypertens
; 41(4): 670-677, 2023 04 01.
Article
in En
| MEDLINE
| ID: mdl-36779344
ABSTRACT
OBJECTIVE:
To evaluate the associations of sleep irregularity with hypertension (HTN) and blood pressure (BP) levels.METHODS:
Adult participants from the ELSA-Brasil performed a clinical evaluation including objective sleep duration (actigraphy), insomnia, and a sleep study for defining obstructive sleep apnoea (OSA). To quantify sleep irregularity, we used two parameters obtained through actigraphy 7-day standard deviation (SD) of sleep duration and 7-day SD of sleep-onset timing. A multivariate analysis was used to determine the independent associations of sleep irregularity with HTN and SBP/DBP values.RESULTS:
We studied 1720 participants (age 49â±â8âyears; 43.4% men) and 27% fulfilled the HTN diagnosis. After adjustments for age, gender, race, BMI, excessive alcohol consumption, physical activity intensity, urinary sodium excretion, insomnia, objective sleep duration and OSA (apnoea-hypopnoea index ≥15âevents/h), we found that the continuous analysis of 7-day SD of sleep duration was modestly associated with prevalent HTN. However, 7-day SD of sleep duration more than 90âmin was independently associated with SBP [ ß 1.55; 95% confidence interval (CI) 0.23-2.88] and DBP ( ß 1.07; 95% CI 0.12-2.01). Stratification analysis excluding participants with OSA revealed that a 7-day SD of sleep duration greater than 90âmin was associated with a 48% higher chance of having HTN (OR 1.48; 95% CI 1.05-2.07). No significant associations were observed for the SD of sleep-onset timing.CONCLUSION:
Objective measurement of sleep irregularity, evaluated by SD of sleep duration for 1 week, was associated with HTN and higher BP levels, especially in participants without OSA.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep Apnea, Obstructive
/
Hypertension
/
Sleep Initiation and Maintenance Disorders
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
J Hypertens
Year:
2023
Document type:
Article