Mutations in <i>Rv0678</i> Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371.

Almeida, Deepak V; Converse, Paul J; Nuermberger, Eric L

Mutations in Rv0678 Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371.

Almeida, Deepak V; Converse, Paul J; Nuermberger, Eric L.

Affiliation

Almeida DV; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Converse PJ; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Nuermberger EL; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Antimicrob Agents Chemother ; 67(3): e0005223, 2023 03 16.

Article in En | MEDLINE | ID: mdl-36786606

Subject(s)

Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant; Humans; Mycobacterium tuberculosis/genetics; Antitubercular Agents/pharmacology; Antitubercular Agents/therapeutic use; Mutation; Bacterial Proteins/genetics; Microbial Sensitivity Tests; Tuberculosis, Multidrug-Resistant/drug therapy

Key words

BTZ043; DprE1; Mycobacterium tuberculosis; OPC-167823; PBTZ169; Rv0678; TBA-7371

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2023 Document type: Article Affiliation country: United States

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