Interleukin-22 alleviates alcohol-associated hepatic fibrosis, inhibits autophagy, and suppresses the PI3K/AKT/mTOR pathway in mice.

Meng, Yu-Xi; Zhao, Rui; Huo, Li-Juan

Meng, Yu-Xi; Zhao, Rui; Huo, Li-Juan.

Affiliation

Meng YX; Shanxi Medical University, Taiyuan, China.
Zhao R; Department of Gastroenterology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Huo LJ; Department of Gastroenterology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China.

Alcohol Clin Exp Res (Hoboken) ; 47(3): 448-458, 2023 Mar.

Article in En | MEDLINE | ID: mdl-36799106

Subject(s)

Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Mice; Male; Animals; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-akt/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Mice, Inbred C57BL; TOR Serine-Threonine Kinases/metabolism; Liver Cirrhosis/chemically induced; Liver Cirrhosis/prevention & control; Ethanol/toxicity; Autophagy; Interleukin-22

Key words

PI3K/AKT/mTOR signaling pathway; alcoholic liver disease; autophagy; hepatic fibrosis; interleukin-22

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Alcohol Clin Exp Res (Hoboken) Year: 2023 Document type: Article Affiliation country: China Country of publication: United States

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