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The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides.
Harada, Kosuke; Furukawa, Hideki; Kohara, Hiroshi; Nishimura, Koki; Komori, Hisakazu; Okai, Yoshiko; Arai, Yuta; Yamamoto, Yuhei; Yamamoto, Katsuhiko; Imanishi, Akio; Shinozawa, Tadahiro.
Affiliation
  • Harada K; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Furukawa H; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kohara H; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Nishimura K; Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Komori H; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Okai Y; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Arai Y; Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yamamoto Y; Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yamamoto K; Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Imanishi A; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Shinozawa T; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: tadahiro.shinozawa@takeda.com.
Toxicol In Vitro ; 89: 105569, 2023 Jun.
Article in En | MEDLINE | ID: mdl-36801361
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytopenia / Oligonucleotides, Antisense Limits: Animals Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytopenia / Oligonucleotides, Antisense Limits: Animals Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom