Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti-CD16 antibody revealed superior antitumor effects toward myeloid leukemia.

Zhang, Rui; Liu, Qingxi; Zhou, Sa; He, Hongpeng; Zhao, Mingfeng; Ma, Wenjian

Zhang, Rui; Liu, Qingxi; Zhou, Sa; He, Hongpeng; Zhao, Mingfeng; Ma, Wenjian.

Affiliation

Zhang R; Department of Hematology, Tianjin First Central Hospital, Tianjin, China.
Liu Q; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China; Qilu Institute of Technology, Shandong, China.
Zhou S; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
He H; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Zhao M; Department of Hematology, Tianjin First Central Hospital, Tianjin, China. Electronic address: mingfengzhao@sina.com.
Ma W; Qilu Institute of Technology, Shandong, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China. Electronic address: ma_wj@tust.edu.cn.

Cancer Lett ; 558: 216103, 2023 04 01.

Article in En | MEDLINE | ID: mdl-36805460

Subject(s)

Killer Cells, Natural; Leukemia, Myeloid, Acute; Humans; Cell Line, Tumor; Cytokines; Cytotoxicity, Immunologic; Immunotherapy, Adoptive; Leukemia, Myeloid, Acute/pathology; Sialic Acid Binding Ig-like Lectin 3; Animals; Receptors, IgG

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Leukemia, Myeloid, Acute Limits: Animals / Humans Language: En Journal: Cancer Lett Year: 2023 Document type: Article Affiliation country: China

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