3'-UTR; 3'-UTR, 3'-untranslated region; AREs, Adenylate-uridylate-rich element(s); ATCC, American Type Culture Collection; ActD, Actinomycin D; CISBP, Catalog of Inferred Sequence Binding Preferences; Ct, Cycle Threshold; DAP3, Death associated protein 3; DEGs, Differentially expressed gene(s); Differentially expressed genes; EHBP1, EH domain binding protein 1; FC, Fold change; FDR, False discovery rate; FPKM, Fragments per kilobase of transcript per million mapped; GFP, Green fluorescent protein; GO, Gene Ontology; HKG, House-keeping genes; HNSCC; HNSCCs, Head and neck squamous cell carcinoma(s); HQ, High quality; IAEC, Institutional animal ethics committee; IFN, Interferon; IGFBP2, Insulin-like growth factor-binding protein 2; IHC, Immunohistochemistry; IP6K2, Inositol hexakisphosphate kinase 2; KD, Knockdown; KEGG, Kyoto encyclopedia of genes and genomics; MAPK, Mitogen-Activated Protein Kinase; MAPKAPK2; MAPKAPK2 or MK2, Mitogen-activated protein kinase-activated protein kinase 2; MELK, Maternal embryonic leucine zipper kinase; MK2KD, MK2-knockdown; MK2WT, MK2 wild-type; MKP-1, Mitogen-activated protein kinase phosphatase-1; MUC4, Mucin 4; NGS, Next generation sequencing; NOD/SCID, Non-obese diabetic/severe combined immunodeficient; PRKAR2B, Protein kinase CAMP-dependent type II regulatory subunit beta; QC, Quality control; RBPs, RNA-binding protein(s); RIN, RNA integrity number; RNA-seq, Ribose Nucleic Acid -sequencing; RNA-sequencing; RT-qPCR, Real-time quantitative polymerase chain reaction; RUNX1, Runt-related transcription factor 1; SLF2, SMC5-SMC6 complex localization factor 2; TCGA, The cancer genome atlas; TNF-α, Tumor necrosis factor-alpha; TTP, Tristetraprolin; Transcriptome; VEGF, Vascular endothelial growth factor; WB, Western blotting; WT, Wild type; ZNF662, Zinc finger protein 662; p27, Cyclin-dependent kinase inhibitor 1B; shRNA, Short hairpin RNA