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Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Yu, Xibao; Liu, Xin; Liu, Xuan; Jin, Shuang; Zhong, Mengjun; Nie, Dingrui; Zeng, Xiangbo; Wang, Xianfeng; Tan, Jiaxiong; Li, Yangqiu; Zeng, Chengwu.
Affiliation
  • Yu X; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China.
  • Liu X; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, China.
  • Liu X; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China.
  • Jin S; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China.
  • Zhong M; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China.
  • Nie D; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
  • Zeng X; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
  • Wang X; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, China.
  • Tan J; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
  • Li Y; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China. Electronic address: yangqiuli@hotmail.com.
  • Zeng C; The First Affiliated Hospital and Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China. Electronic address: bio-zcw@163.com.
Eur J Pharmacol ; 945: 175614, 2023 Apr 15.
Article in En | MEDLINE | ID: mdl-36822457
ABSTRACT
Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer development and management, however, the role of CASP1 and its regulation has not yet been documented for acute promyelocytic leukemia (APL). Here, we found that CASP1/GSDMD had lower expression in patients with APL and most other subtypes of primary de novo acute myeloid leukemia (AML) and was increased in all-trans-retinoic acid (ATRA)-treated APL cells. We showed that ATRA increases and activates CASP1 to trigger the pyroptosis and differentiation of APL cells. Mechanistically, ATRA could induce CASP1 expression via the IFNγ/STAT1 pathway in APL cells. In conclusion, ATRA-induced activation of CASP1 may serve as a suppressor in APL progression, as it triggers pyroptotic cell death and differentiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute Limits: Humans Language: En Journal: Eur J Pharmacol Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute Limits: Humans Language: En Journal: Eur J Pharmacol Year: 2023 Document type: Article Affiliation country: China