Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Eur J Pharmacol
; 945: 175614, 2023 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-36822457
ABSTRACT
Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer development and management, however, the role of CASP1 and its regulation has not yet been documented for acute promyelocytic leukemia (APL). Here, we found that CASP1/GSDMD had lower expression in patients with APL and most other subtypes of primary de novo acute myeloid leukemia (AML) and was increased in all-trans-retinoic acid (ATRA)-treated APL cells. We showed that ATRA increases and activates CASP1 to trigger the pyroptosis and differentiation of APL cells. Mechanistically, ATRA could induce CASP1 expression via the IFNγ/STAT1 pathway in APL cells. In conclusion, ATRA-induced activation of CASP1 may serve as a suppressor in APL progression, as it triggers pyroptotic cell death and differentiation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Promyelocytic, Acute
Limits:
Humans
Language:
En
Journal:
Eur J Pharmacol
Year:
2023
Document type:
Article
Affiliation country:
China