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Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus.
Dai, Quan; Pang, Li-Ting; Zhang, Fa-Lei; Wang, Gang-Qiang; Li, Xue-Mei; Liu, Ji-Kai; Feng, Tao.
Affiliation
  • Dai Q; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Pang LT; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Zhang FL; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Wang GQ; Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100, China.
  • Li XM; Plant Protection and Quarantine Station of Dehong, Dehong 678400, China.
  • Liu JK; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
  • Feng T; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
Molecules ; 28(4)2023 Feb 06.
Article in En | MEDLINE | ID: mdl-36838552
ABSTRACT
Two unusual polyketide-sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC50 values ranging from 5.516 to 19.953 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Basidiomycota Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Basidiomycota Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: China