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Trials and tribulations of statistical significance in biochemistry and omics.
Montero, Olimpio; Hedeland, Mikael; Balgoma, David.
Affiliation
  • Montero O; Unidad de Excelencia, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid, Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
  • Hedeland M; Analytical Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Sweden.
  • Balgoma D; Unidad de Excelencia, Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid, Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain; Analytical Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Sweden. Electronic address: david.balgoma@ilk.uu.se.
Trends Biochem Sci ; 48(6): 503-512, 2023 06.
Article in En | MEDLINE | ID: mdl-36842858
Over recent years many statisticians and researchers have highlighted that statistical inference would benefit from a better use and understanding of hypothesis testing, p-values, and statistical significance. We highlight three recommendations in the context of biochemical sciences. First recommendation: to improve the biological interpretation of biochemical data, do not use p-values (or similar test statistics) as thresholded values to select biomolecules. Second recommendation: to improve comparison among studies and to achieve robust knowledge, perform complete reporting of data. Third recommendation: statistical analyses should be reported completely with exact numbers (not as asterisks or inequalities). Owing to the high number of variables, a better use of statistics is of special importance in omic studies.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Trends Biochem Sci Year: 2023 Document type: Article Affiliation country: Spain Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Trends Biochem Sci Year: 2023 Document type: Article Affiliation country: Spain Country of publication: United kingdom