The impact of haematoxylin-eosin staining and immunohistochemistry of lentigo maligna and lentigo maligna melanoma margins on local recurrence
Eur J Dermatol
; 32(6): 750-755, 2022 11 01.
Article
in En
| MEDLINE
| ID: mdl-36856395
ABSTRACT
Background:
Local recurrence of lentigo maligna melanoma (LMM) and lentigo maligna (LM) continue to be challenging following surgical treatment and aftercare.Objectives:
To investigate haematoxylin-eosin staining and immunohistochemistry of the tumour margins of LM and LMM and evaluate the impact of these data on local recurrence. Materials &Methods:
In total, 489 tumours were included in this retrospective single-centre study, among them 199 (40.7%) LMs and 290 (59.3%) LMMs. All tumours were excised using micrographiccontrolled surgery. Additional immunohistochemistry staining of the tumour margins was performed in 35 specimens (7.2%).Results:
Based on haematoxylin-eosin staining alone, 82/454 tumours (18.1%) were shown to develop local recurrence compared to 3/35 tumours (8.6%) when additional immunohistochemistry was performed.Conclusion:
Following micrographic-controlled surgery, the additional use of immunohistochemistry of tumour margins of LM/LMM reduced the risk of local recurrence, although this was not statistically significant.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Hutchinson's Melanotic Freckle
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Eur J Dermatol
Journal subject:
DERMATOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Germany