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Genome-wide association study of 17 serum biochemical indicators in a chicken F2 resource population.
Song, Haijie; Li, Wenting; Li, Yuanfang; Zhai, Bin; Guo, Yujie; Chen, Yi; Han, Ruili; Sun, Guirong; Jiang, Ruirui; Li, Zhuanjian; Yan, Fengbin; Li, Guoxi; Liu, Xiaojun; Zhang, Yanhua; Tian, Yadong; Kang, Xiangtao.
Affiliation
  • Song H; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Li W; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Li Y; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Zhai B; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Guo Y; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Chen Y; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Han R; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Sun G; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Jiang R; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Li Z; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Yan F; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Li G; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Liu X; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Zhang Y; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Tian Y; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
  • Kang X; College of Animal Science and Technology, Henan Agricultural University, No.15 Longzihu University Area, Zhengzhou New District, 450002, Zhengzhou, China.
BMC Genomics ; 24(1): 98, 2023 Mar 02.
Article in En | MEDLINE | ID: mdl-36864386
ABSTRACT

BACKGROUND:

Serum biochemical indicators are often regarded as direct reflections of animal metabolism and health. The molecular mechanisms underlying serum biochemical indicators metabolism of chicken (Gallus Gallus) have not been elucidated. Herein, we performed a genome-wide association study (GWAS) to identify the variation associated with serum biochemical indicators. The aim of this research was to broaden the understanding of the serum biochemical indicators in chickens.

RESULTS:

A GWAS of serum biochemical indicators was carried out on 734 samples from an F2 Gushi× Anka chicken population. All chickens were genotyped by sequencing, 734 chickens and 321,314 variants were obtained after quality control. Based on these variants, a total of 236 single-nucleotide polymorphisms (SNPs) on 9 chicken chromosomes (GGAs) were identified to be significantly (-log10(P) > 5.72) associated with eight of seventeen serum biochemical indicators. Ten novel quantitative trait locis (QTLs) were identified for the 8 serum biochemical indicator traits of the F2 population. Literature mining revealed that the ALPL, BCHE, GGT2/GGT5 genes at loci GGA24, GGA9 and GGA15 might affect the alkaline phosphatase (AKP), cholinesterase (CHE) and γ-glutamyl transpeptidase (GGT) traits, respectively.

CONCLUSION:

The findings of the present study may contribute to a better understanding of the molecular mechanisms of chicken serum biochemical indicator regulation and provide a theoretical basis for chicken breeding programs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chickens / Genome-Wide Association Study Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2023 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chickens / Genome-Wide Association Study Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2023 Document type: Article Affiliation country: China