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Efficacy and safety of selective JAK 1 inhibitor filgotinib in active rheumatoid arthritis patients with inadequate response to methotrexate: comparative study with filgotinib and tocilizumab examined by clinical index as well as musculoskeletal ultrasound assessment (TRANSFORM study): study protocol for a randomized, open-label, parallel-group, multicenter, and non-inferiority clinical trial.
Shimizu, Toshimasa; Kawashiri, Shin-Ya; Morimoto, Shimpei; Kawazoe, Yurika; Kuroda, Shohei; Kawasaki, Rina; Ito, Yasuko; Kiya, Rieko; Sato, Shuntaro; Yamamoto, Hiroshi; Kawakami, Atsushi.
Affiliation
  • Shimizu T; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Kawashiri SY; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Morimoto S; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. shin-ya@nagasaki-u.ac.jp.
  • Kawazoe Y; Department of Community Medicine, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. shin-ya@nagasaki-u.ac.jp.
  • Kuroda S; Innovation Platform & Office for Precision Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Kawasaki R; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Ito Y; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Kiya R; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Sato S; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Yamamoto H; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Kawakami A; Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
Trials ; 24(1): 161, 2023 Mar 03.
Article in En | MEDLINE | ID: mdl-36869356
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Methotrexate Type of study: Clinical_trials / Guideline / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Methotrexate Type of study: Clinical_trials / Guideline / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom