Post-malnutrition growth and its associations with child survival and non-communicable disease risk: a secondary analysis of the Malawi 'ChroSAM' cohort.
Public Health Nutr
; 26(8): 1658-1670, 2023 08.
Article
in En
| MEDLINE
| ID: mdl-36876519
ABSTRACT
OBJECTIVE:
To explore patterns of post-malnutrition growth (PMGr) during and after treatment for severe malnutrition and describe associations with survival and non-communicable disease (NCD) risk 7 years post-treatment.DESIGN:
Six indicators of PMGr were derived based on a variety of timepoints, weight, weight-for-age z-score and height-for-age z-score (HAZ). Three categorisation methods included no categorisation, quintiles and latent class analysis (LCA). Associations with mortality risk and seven NCD indicators were analysed.SETTING:
Secondary data from Blantyre, Malawi between 2006 and 2014.PARTICIPANTS:
A cohort of 1024 children treated for severe malnutrition (weight-for-length z-score < 70 % median and/or MUAC (mid-upper arm circumference) < 110 mm and/or bilateral oedema) at ages 5-168 months.RESULTS:
Faster weight gain during treatment (g/d) and after treatment (g/kg/day) was associated with lower risk of death (adjusted OR 0·99, 95 % CI 0·99, 1·00; and adjusted OR 0·91, 95 % CI 0·87, 0·94, respectively). In survivors (mean age 9 years), it was associated with greater hand grip strength (0·02, 95 % CI 0·00, 0·03) and larger HAZ (6·62, 95 % CI 1·31, 11·9), both indicators of better health. However, faster weight gain was also associated with increased waisthip ratio (0·02, 95 % CI 0·01, 0·03), an indicator of later-life NCD risk. The clearest patterns of association were seen when defining PMGr based on weight gain in g/d during treatment and using the LCA method to describe growth patterns. Weight deficit at admission was a major confounder.CONCLUSIONS:
A complex pattern of benefits and risks is associated with faster PMGr. Both initial weight deficit and rate of weight gain have important implications for future health.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein-Energy Malnutrition
/
Malnutrition
/
Severe Acute Malnutrition
/
Noncommunicable Diseases
Type of study:
Etiology_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Child
/
Humans
/
Infant
Country/Region as subject:
Africa
Language:
En
Journal:
Public Health Nutr
Journal subject:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Year:
2023
Document type:
Article
Affiliation country:
United kingdom