[Research advances on the mechanism of Wnt/ß-catenin signaling pathway in body surface wound healing].
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
; 39(2): 190-195, 2023 Feb 20.
Article
in Zh
| MEDLINE
| ID: mdl-36878529
ABSTRACT
Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classical pathway. Wnt classical pathway, also known as Wnt/ß-catenin signaling pathway, plays an important role in cell differentiation, cell migration, and maintenance of tissue homeostasis. Many inflammatory factors and growth factors are involved in the upstream regulation of this pathway. The activation of Wnt/ß-catenin signaling pathway plays an important role in the occurrence, development, regeneration, repair and related treatment of skin wounds. This article review the relationship between Wnt/ß-catenin signaling pathway and wound healing, meanwhile summarizes its effects on important processes of wound healing, such as inflammation, cell proliferation, angiogenesis, hair follicle regeneration, and skin fibrosis, as well as the role of inhibitors of Wnt signaling pathway in wound healing.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wnt Signaling Pathway
/
Inflammation
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
Year:
2023
Document type:
Article
Affiliation country:
China