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Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.
Vunnam, Nagamani; Been, MaryJane; Huber, Evan; Paulson, Carolyn; Szymonski, Sophia; Hackel, Benjamin J; Sachs, Jonathan N.
Affiliation
  • Vunnam N; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Been M; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Huber E; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Paulson C; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Szymonski S; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Hackel BJ; Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Sachs JN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Mol Pharm ; 20(4): 1884-1897, 2023 04 03.
Article in En | MEDLINE | ID: mdl-36897792
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States