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Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development.
Zhao, Ninglin; Song, Yingjie; Xie, Xiangqian; Zhu, Ziqi; Duan, Chenxi; Nong, Cheng; Wang, Huan; Bao, Rui.
Affiliation
  • Zhao N; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Song Y; College of Life Science, Sichuan Normal University, Chengdu, China.
  • Xie X; State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center of Nanjing University, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
  • Zhu Z; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Duan C; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Nong C; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • Wang H; State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center of Nanjing University, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. wanghuan@nju.edu.cn.
  • Bao R; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. baorui@scu.edu.cn.
Signal Transduct Target Ther ; 8(1): 112, 2023 03 11.
Article in En | MEDLINE | ID: mdl-36906608
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram and engineer cells for improved performance, novel functions, and diverse applications. Such cell engineering resources can play a critical role in the research and development of novel therapeutics. However, there are certain limitations and challenges in applying genetically engineered cells in clinical practice. This literature review updates the recent advances in biomedical applications, including diagnosis, treatment, and drug development, of SB-inspired cell engineering. It describes technologies and relevant examples in a clinical and experimental setup that may significantly impact the biomedicine field. At last, this review concludes the results with future directions to optimize the performances of synthetic gene circuits to regulate the therapeutic activities of cell-based tools in specific diseases.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Engineering / Drug Development Type of study: Diagnostic_studies Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Affiliation country: China Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Engineering / Drug Development Type of study: Diagnostic_studies Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Affiliation country: China Country of publication: United kingdom