Successful sequential liver and hematopoietic stem cell transplantation in a patient with Fanconi anemia.
Pediatr Transplant
; 27(5): e14503, 2023 08.
Article
in En
| MEDLINE
| ID: mdl-36915258
ABSTRACT
BACKGROUND:
In Fanconi anemia bone marrow failure is the major cause of morbidity and mortality and hematopoietic stem cell transplantation represents the only curative treatment. Liver disease, in terms of elevated liver function tests, as well as benign and malignant liver tumors, occurs especially in case of androgen treatment. We report a unique case of a child with Fanconi anemia with FANCD2 mutation who developed neonatal cryptogenic liver cirrhosis and bone marrow failure. The child successfully underwent sequential liver transplantation and hematopoietic stem cell transplantation in the first 2 years of life. Nineteen months after hematopoietic stem cell transplantation and 30 months after liver transplantation, the patient is clinically well with normal hematopoietic function and excellent liver function.CONCLUSION:
This is the first FA patient who successfully received sequential LT and HSCT highlighting that successful sequential transplantation is feasible in Fanconi anemia patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancytopenia
/
Liver Transplantation
/
Hematopoietic Stem Cell Transplantation
/
Fanconi Anemia
Limits:
Child
/
Humans
/
Newborn
Language:
En
Journal:
Pediatr Transplant
Journal subject:
PEDIATRIA
/
TRANSPLANTE
Year:
2023
Document type:
Article
Affiliation country:
Italy