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Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia.
Pizzi, Marco; Vianello, Fabrizio; Lorenzi, Luisa; Binotto, Gianni; Sbaraglia, Marta; Scarmozzino, Federico; De Crescenzo, Andrea; Guzzardo, Vincenza; Zoletto, Simone; d'Amore, Fabio; Friziero, Alberto; D'Adda, Mariella; Facchetti, Fabio; Dei Tos, Angelo Paolo.
Affiliation
  • Pizzi M; Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Vianello F; Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Lorenzi L; Section of Pathology, Department of Molecular and Translational Medicine, University of Brescia School of Medicine, Spedali Civili di Brescia, Brescia, Italy.
  • Binotto G; Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Sbaraglia M; Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Scarmozzino F; Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • De Crescenzo A; Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Guzzardo V; Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Zoletto S; Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • d'Amore F; Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
  • Friziero A; 1st Surgical Clinic, Department of Surgical Oncological and Gastroenterological Sciences, University of Padua School of Medicine, Padua, Italy.
  • D'Adda M; Haematology Unit, ASST Spedali Civili di Brescia, Brescia, Italy.
  • Facchetti F; Section of Pathology, Department of Molecular and Translational Medicine, University of Brescia School of Medicine, Spedali Civili di Brescia, Brescia, Italy.
  • Dei Tos AP; Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
Br J Haematol ; 202(1): 147-152, 2023 07.
Article in En | MEDLINE | ID: mdl-36916680
ABSTRACT
Accessory spleens (AcS) may play a relevant role in immune thrombocytopenia (ITP) and possibly contribute to ITP relapse following splenectomy. Little is known about the immune microenvironment of AcS in ITP. To address this issue, we compared the histological features of eight matched AcS and main spleen (MS) samples, obtained from adult patients with primary ITP. AcS and MS had overlapping immune architectural features and lymphoid composition, suggesting that similar immunologic events occur in AcS and MS of ITP. These findings may have implications for the potential mechanisms of AcS-mediated ITP relapse. Further studies are needed to confirm these results and to dissect spleen immunity in ITP.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Splenic Diseases / Thrombocytopenia / Purpura, Thrombocytopenic, Idiopathic Limits: Adult / Humans Language: En Journal: Br J Haematol Year: 2023 Document type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Splenic Diseases / Thrombocytopenia / Purpura, Thrombocytopenic, Idiopathic Limits: Adult / Humans Language: En Journal: Br J Haematol Year: 2023 Document type: Article Affiliation country: Italy