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Aberrant survival of hippocampal Cajal-Retzius cells leads to memory deficits, gamma rhythmopathies and susceptibility to seizures in adult mice.
Riva, Martina; Moriceau, Stéphanie; Morabito, Annunziato; Dossi, Elena; Sanchez-Bellot, Candela; Azzam, Patrick; Navas-Olive, Andrea; Gal, Beatriz; Dori, Francesco; Cid, Elena; Ledonne, Fanny; David, Sabrina; Trovero, Fabrice; Bartolomucci, Magali; Coppola, Eva; Rebola, Nelson; Depaulis, Antoine; Rouach, Nathalie; de la Prida, Liset Menendez; Oury, Franck; Pierani, Alessandra.
Affiliation
  • Riva M; Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, 75015, Paris, France.
  • Moriceau S; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, 75014, Paris, France.
  • Morabito A; Platform for Neurobehavioral and metabolism, Structure Fédérative de Recherche Necker, 26 INSERM US24/CNRS UAR, 3633, Paris, France.
  • Dossi E; Sorbonne Université, Institut Du Cerveau-Paris Brain Institute-ICM, Inserm U1127, CNRS UMR 7225, 47 Boulevard de l'Hopital, 75013, Paris, France.
  • Sanchez-Bellot C; Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Labex Memolife, Université PSL, Paris, France.
  • Azzam P; Instituto Cajal, CSIC, Madrid, Spain.
  • Navas-Olive A; Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, 75015, Paris, France.
  • Gal B; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, 75014, Paris, France.
  • Dori F; Instituto Cajal, CSIC, Madrid, Spain.
  • Cid E; Instituto Cajal, CSIC, Madrid, Spain.
  • Ledonne F; Universidad Camilo José Cela, Madrid, Spain.
  • David S; Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, 75015, Paris, France.
  • Trovero F; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, 75014, Paris, France.
  • Bartolomucci M; Instituto Cajal, CSIC, Madrid, Spain.
  • Coppola E; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, 75014, Paris, France.
  • Rebola N; Key-Obs SAS, 13 avenue Buffon, 45100, Orléans, France.
  • Depaulis A; Key-Obs SAS, 13 avenue Buffon, 45100, Orléans, France.
  • Rouach N; Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000, Grenoble, France.
  • de la Prida LM; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, 75014, Paris, France.
  • Oury F; Sorbonne Université, Institut Du Cerveau-Paris Brain Institute-ICM, Inserm U1127, CNRS UMR 7225, 47 Boulevard de l'Hopital, 75013, Paris, France.
  • Pierani A; Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000, Grenoble, France.
Nat Commun ; 14(1): 1531, 2023 03 18.
Article in En | MEDLINE | ID: mdl-36934089
Cajal-Retzius cells (CRs) are transient neurons, disappearing almost completely in the postnatal neocortex by programmed cell death (PCD), with a percentage surviving up to adulthood in the hippocampus. Here, we evaluate CR's role in the establishment of adult neuronal and cognitive function using a mouse model preventing Bax-dependent PCD. CRs abnormal survival resulted in impairment of hippocampus-dependent memory, associated in vivo with attenuated theta oscillations and enhanced gamma activity in the dorsal CA1. At the cellular level, we observed transient changes in the number of NPY+ cells and altered CA1 pyramidal cell spine density. At the synaptic level, these changes translated into enhanced inhibitory currents in hippocampal pyramidal cells. Finally, adult mutants displayed an increased susceptibility to lethal tonic-clonic seizures in a kainate model of epilepsy. Our data reveal that aberrant survival of a small proportion of postnatal hippocampal CRs results in cognitive deficits and epilepsy-prone phenotypes in adulthood.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hippocampus / Neurons Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: France Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hippocampus / Neurons Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: France Country of publication: United kingdom