Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA.
Nucleic Acids Res
; 51(13): 6509-6527, 2023 07 21.
Article
in En
| MEDLINE
| ID: mdl-36940725
A key feature of all cancer cells is their ability to divide indefinitely, and this is dependent on circumvention of telomere shortening through induction of a telomere maintenance mechanism, such as the telomerase-independent, Alternative Lengthening of Telomeres (ALT) pathway. The ALT pathway is characterised by loss of the ATRX chromatin remodeler. The current study provides evidence that, in the absence of ATRX, increased trapping of proteins on DNA leads to replication fork stalling and collapse. At telomeres, this leads to ALT pathway activity. These results help to better understand ALT tumours and might, eventually, be instrumental in developing new therapeutic strategies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Telomere
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Nucleic Acids Res
Year:
2023
Document type:
Article
Affiliation country:
United kingdom
Country of publication:
United kingdom