Targeting autophagy receptors OPTN and SQSTM1 as a novel therapeutic strategy for osteoporosis complicated with Alzheimer's disease.
Chem Biol Interact
; 377: 110462, 2023 May 25.
Article
in En
| MEDLINE
| ID: mdl-36958424
ABSTRACT
Alzheimer's disease (AD) is a common degenerative disease among the elderly population. In addition to cognitive impairment, AD is often accompanied by behavioral manifestations. However, little attention has been paid to changes in bone metabolism and related mechanisms in patients with AD. We found that AD mice (APPswe/PS1dE9) had reduced bone density, weakened bone strength, and amyloid beta (Aß) deposition in the bone tissue. It was further found that targeting autophagy receptors Optineurin (OPTN) and Sequestosome 1 (SQSTM1) increased bone density and bone strength in AD mice, promoted the clearance of Aß in the bone tissue, and maintained bone homeostasis. Our study suggests that abnormal Aß deposition may be the co-pathogenesis of AD and osteoporosis (OP). Targeting OPTN and SQSTM1 has a dual-functional effect of alleviating both AD and OP through selective autophagy that specifically targets Aß for clearance. Therapeutic strategies targeting autophagy may help guide the treatment of patients with AD complicated with OP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Alzheimer Disease
Limits:
Aged
/
Animals
/
Humans
Language:
En
Journal:
Chem Biol Interact
Year:
2023
Document type:
Article
Affiliation country:
China