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EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort.
Agrawal, Prashasti; David, Kevin A; Chen, Zhengming; Sundaram, Suchitra; Kim, Seo-Hyun; Vaca, Ryan; Lin, Yong; Singer, Samuel; Malecek, Mary-Kate; Carter, Jordan; Zayac, Adam; Kim, Myung Sun; Reddy, Nishitha; Ney, Douglas; Habib, Alma; Strouse, Christopher; Graber, Jerome; Bachanova, Veronika; Salman, Sidra; Vendiola, Jean A; Hossain, Nasheed; Tsang, Mazie; Major, Ajay; Gandhi, Maher K; Keane, Colm; Bond, David A; Folstad, Matthew; Chang, Julie; Mier-Hicks, Angel; Torka, Pallawi; Rajakumar, Priya; Venugopal, Parameswaran; Berg, Stephanie; Glantz, Michael; Goldlust, Samuel A; Matnani, Rahul; Kumar, Pallavi; Ollila, Thomas A; Cai, Johnny; Spurgeon, Stephen E; Sieg, Alex G; Cleveland, Joseph; Epperla, Narendranath; Karmali, Reem; Naik, Seema; Smith, Sonali M; Rubenstein, James L; Kahl, Brad S; Chadburn, Amy; Evens, Andrew M.
Affiliation
  • Agrawal P; Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
  • David KA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Chen Z; Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
  • Sundaram S; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Kim SH; Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.
  • Vaca R; Department of Medicine, Penn State University College of Medicine, Hershey, PA, USA.
  • Lin Y; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Singer S; John Theurer Cancer Center, Hackensack, NJ, USA.
  • Malecek MK; Department of Medicine, Division of Hematology & Oncology, Washington University School of Medicine, University City, MO, USA.
  • Carter J; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
  • Zayac A; Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
  • Kim MS; Department of Internal Medicine, Oregon Health and Science University, Portland, OR, USA.
  • Reddy N; Department of Medicine, Division of Hematology & Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ney D; Department of Neurology, University of Colorado, Aurora, CO, USA.
  • Habib A; Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota School of Medicine, Minneapolis, MN, USA.
  • Strouse C; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
  • Graber J; Department of Neurology, University of Washington, Seattle, WA, USA.
  • Bachanova V; Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota School of Medicine, Minneapolis, MN, USA.
  • Salman S; Department of Medicine and Cancer Biology, Loyola University, Chicago, IL, USA.
  • Vendiola JA; Department of Medicine and Cancer Biology, Loyola University, Chicago, IL, USA.
  • Hossain N; Department of Medicine and Cancer Biology, Loyola University, Chicago, IL, USA.
  • Tsang M; Department of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.
  • Major A; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
  • Gandhi MK; Princess Alexandria Hospital, Brisbane, Australia.
  • Keane C; Princess Alexandria Hospital, Brisbane, Australia.
  • Bond DA; Department of Medicine, Division of Hematology, The Ohio State University, Columbus, OH, USA.
  • Folstad M; Department of Medicine, Division of Hematology, Oncology and Palliative Care, University of Wisconsin, Madison, WI, USA.
  • Chang J; Department of Medicine, Division of Hematology, Oncology and Palliative Care, University of Wisconsin, Madison, WI, USA.
  • Mier-Hicks A; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Torka P; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Rajakumar P; Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.
  • Venugopal P; Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.
  • Berg S; Department of Medicine and Cancer Biology, Loyola University, Chicago, IL, USA.
  • Glantz M; Department of Medicine, Penn State University College of Medicine, Hershey, PA, USA.
  • Goldlust SA; John Theurer Cancer Center, Hackensack, NJ, USA.
  • Matnani R; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Kumar P; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Ollila TA; Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
  • Cai J; Department of Internal Medicine, Oregon Health and Science University, Portland, OR, USA.
  • Spurgeon SE; Department of Internal Medicine, Oregon Health and Science University, Portland, OR, USA.
  • Sieg AG; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
  • Cleveland J; Department of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.
  • Epperla N; Department of Medicine, Division of Hematology, The Ohio State University, Columbus, OH, USA.
  • Karmali R; Division of Hematology Oncology, Northwestern University, Chicago, IL, USA.
  • Naik S; Department of Medicine, Penn State University College of Medicine, Hershey, PA, USA.
  • Smith SM; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
  • Rubenstein JL; Department of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.
  • Kahl BS; Department of Medicine, Division of Hematology & Oncology, Washington University School of Medicine, University City, MO, USA.
  • Chadburn A; Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
  • Evens AM; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Leuk Lymphoma ; 64(5): 1026-1034, 2023 05.
Article in En | MEDLINE | ID: mdl-36960939
ABSTRACT
The objective of this multicenter retrospective study was to examine the incidence, patient characteristics, pathology, and outcomes associated with Epstein-Barr virus (EBV)-related CNS lymphoma (CNSL) in older patients. Among 309 CNSL patients aged ≥60, 11.7% had EBV + tumors of which 72.2% were solid organ transplant (SOT)-related post-transplant lymphoproliferative disorders (PTLD). Younger age, SOT or autoimmune disease, and immunosuppressive treatment correlated highly with EBV-positivity. EBV + tumors were associated with absent C-MYC and BCL6 expression. EBV + PTLD was more likely to be associated with the absence of CD5 expression. EBV + non-PTLD had better median OS (not reached) compared to EBV + PTLD (10.8 months) and EBV-negative patients (43 months). Multivariable Cox regression analysis showed that age, performance status, and PTLD were negative predictors of OS. EBV status and immunosuppressive treatment were not correlated with OS. Our findings merit further investigation of EBV + PCNSL tumors and EBV-directed therapies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epstein-Barr Virus Infections / Lymphoma / Lymphoproliferative Disorders Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epstein-Barr Virus Infections / Lymphoma / Lymphoproliferative Disorders Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2023 Document type: Article Affiliation country: United States