Image processing and quantification analysis for optical coherence tomography angiography in epiretinal membrane.
Photodiagnosis Photodyn Ther
; 42: 103534, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-36965759
ABSTRACT
BACKGROUND:
To explore image processing methods for optical coherence tomography angiography (OCTA) of the epiretinal membrane (ERM), and to evaluate the impact of ERM on vision by analyzing the retinal vasculature.METHODS:
Thirty eyes of 30 patients with idiopathic ERM who underwent OCTA were retrospectively evaluated. Image processing of OCTA, including the Mexican hat filter (MHF) and exclusion of the foveal avascular zone (FAZ), was attempted using Fiji. OCTA parameters, including vessel density (VD), fractal dimension (FD), and vessel tortuosity (VT), were measured for large vessels only, capillaries only, and the whole vasculature. Pearson correlation analysis was used to evaluate the correlations between best-corrected visual acuity (BCVA) and OCTA parameters.RESULTS:
The correlations between BCVA and retinal vasculature were much increased when the capillaries only instead of the whole vasculature was used for analysis. Both higher VD and FD of capillaries were correlated with better BCVA, and MHF largely increased their correlations (P < 0.0001 for both). In contrast, both higher VD and FD of the large vessels were associated with poorer BCVA (P = 0.042 and 0.049, respectively). A higher VT of capillaries was correlated with better BCVA, and both MHF and exclusion of the FAZ were necessary to reveal their correlations (P = 0.028)CONCLUSIONS:
Separation of large vessels and capillaries was necessary to reveal the correlations between retinal vasculature and BCVA in ERM. MHF was necessary to elucidate all microvascular parameters of capillaries, and exclusion of the FAZ was mandatory for evaluation of VT.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Epiretinal Membrane
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Photodiagnosis Photodyn Ther
Journal subject:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Year:
2023
Document type:
Article
Affiliation country:
Taiwan