Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers.

Karollus, Alexander; Mauermeier, Thomas; Gagneur, Julien

Karollus, Alexander; Mauermeier, Thomas; Gagneur, Julien.

Affiliation

Karollus A; School of Computation, Information and Technology, Technical University of Munich, Garching, Germany. alexander.karollus@tum.de.
Mauermeier T; School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.
Gagneur J; School of Computation, Information and Technology, Technical University of Munich, Garching, Germany. gagneur@in.tum.de.

Genome Biol ; 24(1): 56, 2023 03 27.

Article in En | MEDLINE | ID: mdl-36973806

Subject(s)

Enhancer Elements, Genetic; Genomics; Humans; Genomics/methods; Promoter Regions, Genetic; Gene Expression Regulation; Gene Expression

Key words

Deep learning; Enhancer; Gene expression; Promoter; Transcription; Variant effect

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enhancer Elements, Genetic / Genomics Type of study: Guideline / Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Genome Biol Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google