Drug substitution and adjuvant therapy in patients with genetics related infertility: A review.
Drug Discov Ther
; 17(2): 73-86, 2023 May 15.
Article
in En
| MEDLINE
| ID: mdl-36990765
ABSTRACT
With the in-depth study of the human genome and the increasing popularity of gene sequencing, it has been gradually confirmed that genetics can play a crucial role in infertility. To provide references for clinical treatment, we have focused on genes and drug therapy for genetic infertility. This review recommends adjuvant therapy and drug substitution. Examples of these therapies include antioxidants (such as folic acid, vitamin D, vitamin E, inositol, coenzyme Q10 etc.), metformin, anticoagulants, levothyroxine, dehydroepiandrosterone, glucocorticoids, and gonadotropins etc. Based on the pathogenesis, we provide an overview of the current knowledge, including randomized controlled trials and systematic reviews, and predict potential target genes and signaling pathways, proposing possible future strategies for the use of targeted drugs to treat infertility. Non-coding RNAs are anticipated to become a novel target for the treatment of reproductive illnesses since they have a significant role in controlling the occurrence and development of reproductive diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Substitution
/
Infertility
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Drug Discov Ther
Year:
2023
Document type:
Article
Affiliation country:
China