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Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.
Gomez-Lopez, Nardhy; Romero, Roberto; Escobar, María Fernanda; Carvajal, Javier Andres; Echavarria, Maria Paula; Albornoz, Ludwig L; Nasner, Daniela; Miller, Derek; Gallo, Dahiana M; Galaz, Jose; Arenas-Hernandez, Marcia; Bhatti, Gaurav; Done, Bogdan; Zambrano, Maria Andrea; Ramos, Isabella; Fernandez, Paula Andrea; Posada, Leandro; Chaiworapongsa, Tinnakorn; Jung, Eunjung; Garcia-Flores, Valeria; Suksai, Manaphat; Gotsch, Francesca; Bosco, Mariachiara; Than, Nandor Gabor; Tarca, Adi L.
Affiliation
  • Gomez-Lopez N; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Detroit, MI,
  • Romero R; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA. ngomezlo@med.wayne.edu.
  • Escobar MF; Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, USA. ngomezlo@med.wayne.edu.
  • Carvajal JA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA. ngomezlo@med.wayne.edu.
  • Echavarria MP; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Detroit, MI,
  • Albornoz LL; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA. romeror@mail.nih.gov.
  • Nasner D; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. romeror@mail.nih.gov.
  • Miller D; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. romeror@mail.nih.gov.
  • Gallo DM; Detroit Medical Center, Detroit, MI, USA. romeror@mail.nih.gov.
  • Galaz J; Departamento de Ginecología y Obstetricia, Fundación Valle del Lili, Cali, Colombia.
  • Arenas-Hernandez M; Departamento de Ginecología y Obstetricia, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Bhatti G; Departamento de Ginecología y Obstetricia, Fundación Valle del Lili, Cali, Colombia.
  • Done B; Departamento de Ginecología y Obstetricia, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Zambrano MA; Departamento de Ginecología y Obstetricia, Fundación Valle del Lili, Cali, Colombia.
  • Ramos I; Departamento de Ginecología y Obstetricia, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Fernandez PA; Departamento de Laboratorio Clínico y Patología, Fundación Valle del Lili, Cali, Colombia.
  • Posada L; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
  • Chaiworapongsa T; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.
  • Jung E; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Detroit, MI,
  • Garcia-Flores V; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Suksai M; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Detroit, MI,
  • Gotsch F; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Bosco M; Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Detroit, MI,
  • Than NG; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Tarca AL; Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Commun Med (Lond) ; 3(1): 48, 2023 Apr 04.
Article in En | MEDLINE | ID: mdl-37016066
Pregnant COVID-19 patients are at increased risk of experiencing complications and severe outcomes compared to the general population. However, the reasons for this heightened risk are still unclear. We measured the proteins present in the blood of pregnant and non-pregnant patients with COVID-19 and compared these to healthy individuals. We found that some COVID-19-associated proteins were present at lower levels in pregnant women, which could help to protect the fetus from harmful inflammation, the body's natural response to infection. While some proteins affected by COVID-19 are shared between pregnant and non-pregnant patients, others were distinctly affected only in pregnant women, providing a potential explanation for the more severe outcomes in this group.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Commun Med (Lond) Year: 2023 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Commun Med (Lond) Year: 2023 Document type: Article Country of publication: United kingdom