Acute, next-generation AMPK activation initiates a disease-resistant gene expression program in dystrophic skeletal muscle.

Ng, Sean Y; Mikhail, Andrew I; Mattina, Stephanie R; Manta, Alexander; Diffey, Ian J; Ljubicic, Vladimir

Ng, Sean Y; Mikhail, Andrew I; Mattina, Stephanie R; Manta, Alexander; Diffey, Ian J; Ljubicic, Vladimir.

Affiliation

Ng SY; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Mikhail AI; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Mattina SR; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Manta A; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Diffey IJ; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Ljubicic V; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

FASEB J ; 37(5): e22863, 2023 05.

Article in En | MEDLINE | ID: mdl-37016990

Subject(s)

AMP-Activated Protein Kinases; Muscular Dystrophy, Duchenne; Mice; Animals; AMP-Activated Protein Kinases/genetics; AMP-Activated Protein Kinases/metabolism; Mice, Inbred mdx; Muscle, Skeletal/metabolism; Muscular Dystrophy, Duchenne/drug therapy; Muscular Dystrophy, Duchenne/genetics; Muscular Dystrophy, Duchenne/metabolism; Utrophin/metabolism; Gene Expression; Disease Models, Animal

Key words

PGC-1α; autophagy; muscular dystrophy; myogenic regulatory factors; utrophin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscular Dystrophy, Duchenne / AMP-Activated Protein Kinases Type of study: Prognostic_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2023 Document type: Article Affiliation country: Canada

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