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Cytotoxic steroids from the stems of Strophanthus divaricatus.
Ran, Hong-Ling; Huang, Sheng-Zhuo; Wang, Hao; Yang, Li; Gai, Cui-Juan; Duan, Rui-Jun; Dai, Hao-Fu; Guan, Ya-Li; Mei, Wen-Li.
Affiliation
  • Ran HL; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Huang SZ; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Wang H; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Yang L; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Gai CJ; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Duan RJ; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Dai HF; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
  • Guan YL; Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou, 571158, PR China. Electronic address: 544758563@qq.com.
  • Mei WL; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences & Key Laboratory for Conservation and Utilization of Tropical Agro-bioresources of Hainan P
Phytochemistry ; 210: 113668, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37019169
ABSTRACT
Phytochemical investigation on the stems of Strophanthus divaricatus led to the isolation of four undescribed cardiac glycosides and one undescribed C21 pregnane, together with eleven known steroids. Their structures were elucidated by a comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 16 was determined by comparison of the experimental and computed ECD spectra. Compounds 1-13 and 15 displayed potent to significant cytotoxicity against human cancer cell lines K562, SGC-7901, A549 and HeLa with IC50 values of 0.02-16.08, 0.04-23.13, 0.06-22.31 and 0.06-15.13 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Strophanthus / Antineoplastic Agents Limits: Humans Language: En Journal: Phytochemistry Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Strophanthus / Antineoplastic Agents Limits: Humans Language: En Journal: Phytochemistry Year: 2023 Document type: Article