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The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells.
Talwar, Deepti; Miller, Colin G; Grossmann, Justus; Szyrwiel, Lukasz; Schwecke, Torsten; Demichev, Vadim; Mikecin Drazic, Ana-Matea; Mayakonda, Anand; Lutsik, Pavlo; Veith, Carmen; Milsom, Michael D; Müller-Decker, Karin; Mülleder, Michael; Ralser, Markus; Dick, Tobias P.
Affiliation
  • Talwar D; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Miller CG; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Grossmann J; Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Szyrwiel L; Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Schwecke T; Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Demichev V; Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Mikecin Drazic AM; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Mayakonda A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.
  • Lutsik P; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Veith C; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Milsom MD; Laboratory of Computational Cancer Biology and Epigenomics, Department of Oncology, Catholic University (KU) Leuven, Leuven, Belgium.
  • Müller-Decker K; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Mülleder M; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Ralser M; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.
  • Dick TP; Core Facility Tumor Models, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nat Metab ; 5(4): 660-676, 2023 04.
Article in En | MEDLINE | ID: mdl-37024754
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / Glyceraldehyde-3-Phosphate Dehydrogenases Limits: Animals / Humans Language: En Journal: Nat Metab Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine / Glyceraldehyde-3-Phosphate Dehydrogenases Limits: Animals / Humans Language: En Journal: Nat Metab Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Germany