Silicon switch: Carbon-silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug-like properties in anticancer pharmacophores.

Fotie, Jean; Matherne, Caitlyn M; Wroblewski, Jordan E

Fotie, Jean; Matherne, Caitlyn M; Wroblewski, Jordan E.

Affiliation

Fotie J; Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, Louisiana, USA.
Matherne CM; Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, Louisiana, USA.
Wroblewski JE; Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, Louisiana, USA.

Chem Biol Drug Des ; 102(2): 235-254, 2023 08.

Article in En | MEDLINE | ID: mdl-37029092

Subject(s)

Drug Design; Silicon; Silicon/chemistry; Pharmacophore; Carbon; Drug Discovery

Key words

ADMET profile refining; Bioisosteric silicon switch; anticancer agents; in silico modeling; selectivity modulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silicon / Drug Design Language: En Journal: Chem Biol Drug Des Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom

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